Generation of Th1 T cell responses directed to a HLA Class II restricted epitope from the Aspergillus f16 allergen

HLA class II-restricted CD4+ T cell responses directed against influenza viral antigens postinfluenza vaccination.

The memory T cell response is polyclonal, with the magnitude and specificity of the response controlled in part by the burst size of T cells expanded from effector/memory precursors. Sensitive assays using HLA class II multimers were used to detect low-frequency Ag-specific T cells directed against influenza viral Ags in subjects immunized with the influenza vaccine. Direct ex vivo tetramer sta...

Restricted T Cell Responses to − HLA - A * 0201 Deficiency Augments

Re-evaluating the generation of a "proteasome-independent" MHC class I-restricted CD8 T cell epitope.

The proteasome is primarily responsible for the generation of MHC class I-restricted CTL epitopes. However, some epitopes, such as NP(147-155) of the influenza nucleoprotein (NP), are presented efficiently in the presence of proteasome inhibitors. The pathways used to generate such apparently "proteasome-independent" epitopes remain poorly defined. We have examined the generation of NP(147-155)...

Rapid epitope identification from complex class-II-restricted T-cell antigens.

The identification of CD4 + + T-cell epitopes is a laborious and tedious process. Various computer-assisted algorithms have been designed to assist in this process by predicting potential MHC-binding epitopes. Recently, the novel approach of using soluble MHC class II tetramers as a tool to identify T-cell epitopes has been developed successfully. We show that the T-cell epitopes identified usi...

from linguistics to literature: a linguistic approach to the study of linguistic deviations in the turkish divan of shahriar

chapter i provides an overview of structural linguistics and touches upon the saussurean dichotomies with the final goal of exploring their relevance to the stylistic studies of literature. to provide evidence for the singificance of the study, chapter ii deals with the controversial issue of linguistics and literature, and presents opposing views which, at the same time, have been central to t...